U2 2130 then BY 2648 at Manchester
Pisa → Manchester → Paphos
Timetable, Manchester time
12:15U2 2130 from Pisa at the gate
07:00BY 2648 to Paphos leaves the gate
18 h 45 apart on the timetable, overnight
BY 2648 leaves 18 h 45 after U2 2130 arrives on the timetable: more than half a day, so not a connection we count.