U2 2130 then LS 891 at Manchester
Pisa → Manchester → Lanzarote
Timetable, Manchester time
12:15U2 2130 from Pisa at the gate
10:20LS 891 to Lanzarote leaves the gate
22 h 05 apart on the timetable, overnight
LS 891 leaves 22 h 05 after U2 2130 arrives on the timetable: more than half a day, so not a connection we count.