U2 2166 then FR 6816 at Manchester
Amsterdam → Manchester → Milan
Timetable, Manchester time
16:00U2 2166 from Amsterdam at the gate
15:40FR 6816 to Milan leaves the gate
23 h 40 apart on the timetable, overnight
FR 6816 leaves 23 h 40 after U2 2166 arrives on the timetable: more than half a day, so not a connection we count.