U2 2196 then TK 1992 at Manchester
Hamburg → Manchester → Istanbul
Timetable, Manchester time
21:20U2 2196 from Hamburg at the gate
14:00TK 1992 to Istanbul leaves the gate
16 h 40 apart on the timetable, overnight
TK 1992 leaves 16 h 40 after U2 2196 arrives on the timetable: more than half a day, so not a connection we count.