U2 2196 then U2 2273 at Manchester
Hamburg → Manchester → Valletta
Timetable, Manchester time
17:40U2 2196 from Hamburg at the gate
15:50U2 2273 to Valletta leaves the gate
22 h 10 apart on the timetable, overnight
U2 2273 leaves 22 h 10 after U2 2196 arrives on the timetable: more than half a day, so not a connection we count.