U2 2202 then LS 883 at Manchester
Berlin → Manchester → Pisa
Timetable, Manchester time
22:55U2 2202 from Berlin at the gate
15:15LS 883 to Pisa leaves the gate
16 h 20 apart on the timetable, overnight
LS 883 leaves 16 h 20 after U2 2202 arrives on the timetable: more than half a day, so not a connection we count.