U2 2202 then LS 887 at Manchester
Berlin → Manchester → Prague
Timetable, Manchester time
22:55U2 2202 from Berlin at the gate
15:05LS 887 to Prague leaves the gate
16 h 10 apart on the timetable, overnight
LS 887 leaves 16 h 10 after U2 2202 arrives on the timetable: more than half a day, so not a connection we count.