U2 2216 then FR 1593 at Manchester
Faro → Manchester → Cologne
Timetable, Manchester time
13:55U2 2216 from Faro at the gate
11:00FR 1593 to Cologne leaves the gate
21 h 05 apart on the timetable, overnight
FR 1593 leaves 21 h 05 after U2 2216 arrives on the timetable: more than half a day, so not a connection we count.