U2 2216 then FR 4370 at Manchester
Faro → Manchester → Seville
Timetable, Manchester time
13:55U2 2216 from Faro at the gate
10:30FR 4370 to Seville leaves the gate
20 h 35 apart on the timetable, overnight
FR 4370 leaves 20 h 35 after U2 2216 arrives on the timetable: more than half a day, so not a connection we count.