U2 2216 then FR 641 at Manchester
Faro → Manchester → Valencia
Timetable, Manchester time
14:15U2 2216 from Faro at the gate
09:05FR 641 to Valencia leaves the gate
18 h 50 apart on the timetable, overnight
FR 641 leaves 18 h 50 after U2 2216 arrives on the timetable: more than half a day, so not a connection we count.