U2 2226 then FR 6816 at Manchester
Napoli → Manchester → Milan
Timetable, Manchester time
13:25U2 2226 from Napoli at the gate
06:40FR 6816 to Milan leaves the gate
17 h 15 apart on the timetable, overnight
FR 6816 leaves 17 h 15 after U2 2226 arrives on the timetable: more than half a day, so not a connection we count.