U2 2268 then FR 6816 at Manchester
Gibraltar → Manchester → Milan
Timetable, Manchester time
13:55U2 2268 from Gibraltar at the gate
06:40FR 6816 to Milan leaves the gate
16 h 45 apart on the timetable, overnight
FR 6816 leaves 16 h 45 after U2 2268 arrives on the timetable: more than half a day, so not a connection we count.