U2 2280 then LX 381 at Manchester
Paphos → Manchester → Zurich
Timetable, Manchester time
01:45U2 2280 from Paphos at the gate
18:45LX 381 to Zurich leaves the gate
17 h apart on the timetable
LX 381 leaves 17 h after U2 2280 arrives on the timetable: more than half a day, so not a connection we count.