U2 2280 then U2 2129 at Manchester
Paphos → Manchester → Pisa
Timetable, Manchester time
17:45U2 2280 from Paphos at the gate
06:35U2 2129 to Pisa leaves the gate
12 h 50 apart on the timetable, overnight
U2 2129 leaves 12 h 50 after U2 2280 arrives on the timetable: more than half a day, so not a connection we count.