AA 2221 then K4 221 at O'Hare
Charleston (South Carolina) → Chicago → Cincinnati Northern Kentucky
Timetable, Chicago time
18:01AA 2221 from Charleston (South Carolina) at the gate
16:20K4 221 to Cincinnati Northern Kentucky leaves the gate
22 h 19 apart on the timetable, overnight
K4 221 leaves 22 h 19 after AA 2221 arrives on the timetable: more than half a day, so not a connection we count.