AA 2221 then QR 76 at O'Hare
Charleston (South Carolina) → Chicago → Milan
Timetable, Chicago time
18:01AA 2221 from Charleston (South Carolina) at the gate
14:45QR 76 to Milan leaves the gate
20 h 44 apart on the timetable, overnight
QR 76 leaves 20 h 44 after AA 2221 arrives on the timetable: more than half a day, so not a connection we count.