AA 2278 then QR 76 at O'Hare
Puerto Vallarta → Chicago → Milan
Timetable, Chicago time
21:00AA 2278 from Puerto Vallarta at the gate
14:45QR 76 to Milan leaves the gate
17 h 45 apart on the timetable, overnight
QR 76 leaves 17 h 45 after AA 2278 arrives on the timetable: more than half a day, so not a connection we count.