QR 31 then AA 2221 at O'Hare
Milan → Chicago → Charleston (South Carolina)
Timetable, Chicago time
19:30QR 31 from Milan at the gate
12:06AA 2221 to Charleston (South Carolina) leaves the gate
16 h 36 apart on the timetable, overnight
AA 2221 leaves 16 h 36 after QR 31 arrives on the timetable: more than half a day, so not a connection we count.